Urolithin A Reduces Inflammation

Role of Foods, Fruits, Microbiota, and Gut Health and Inflammation

We discussed the amazing molecule Urolithin A. This molecule triggers autophagy to reduce inflammation, triggers mitophagy to heal mitochondrial disease, and triggers lysophagy to improve cell's recycling activities. The result is better neuronal protection, better muscle strength and efficiency, and reduced inflammation. In cancer cells this molecule triggers apoptosis leading to reduced cancer cell viability or death.

Thank you for joining me on zoom to learn about this molecule. References for the talk are following.

URL list from Wednesday, Nov. 6 2024 11:40 AM

DrBeen: Online Personalized Medical Education - DrBeen
https://www.drbeen.com/

Targeting aging with urolithin A in humans: A systematic review - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S1568163724002241

mTOR and autophagy: A dynamic relationship governed by nutrients and energy - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S1084952114002420

Discovery of the molecular mechanisms responsible for deficient autophagy and the protective effect of urolithin A in age-related macular degeneration | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas
https://www.cib.csic.es/news/research/discovery-molecular-mechanisms-responsible-deficient-autophagy-and-protective-effect

Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration | Molecular Neurodegeneration | Full Text
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-024-00739-3

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0891584919325444

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0304416517303276

Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0944711324003805#:~:text=Urolithin%20A%20mediates%20autophagy%20and,Bip%2C%20markers%20of%20ER%20stress.

Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC10609777/#:~:text=In%20conclusion%2C%20Urolithin%20A%20regulates,JNK%2Fp38%20MAPK%20signaling%20pathways.

Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC5814919/

Frontiers | Urolithin A targets the AKT/WNK1 axis to induce autophagy and exert anti-tumor effects in cholangiocarcinoma
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.963314/full

Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway - Zhang - 2023 - Drug Development Research - Wiley Online Library
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/ddr.22021

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - PubMed
https://pubmed.ncbi.nlm.nih.gov/35584623/

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC6698978/

Urolithin A alleviates neuropathic pain and activates mitophagy - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC10387767/

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions - Hou - 2024 - Alzheimer's & Dementia - Wiley Online Library
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13847

Urolithin-A-Cognitive-Vitality-For-Researchers.pdf
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Urolithin-A-Cognitive-Vitality-For-Researchers.pdf

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice | Journal of Neuroinflammation | Full Text
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1450-3