Tumor Cells Cause Cytotoxic T Cell Exhaustion

A mindboggling new study

Aug 10, 2023

Super Beens,

Thank you for joining the zoom sessions yesterdays to discuss this topic. I loved this study. It was mind boggling for me to find out how quickly a tumor cell can exhaust a cytotoxic T cell. For those that did not join: within 6h of these two cells coming in contact with each other the T cells start becoming exhausted.

Reference links for the talks yesterday:

Tumor Specific T Cell Exhaustion

URL list from Wednesday, Aug. 9 2023

DrBeen: Online Personalized Medical Education

https://drbeen.com/

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

https://theconversation.com/immune-cells-that-fight-cancer-become-exhausted-within-hours-of-first-encountering-tumors-new-research-210947

Defining ‘T cell exhaustion’ | Nature Reviews Immunology

https://www.nature.com/articles/s41577-019-0221-9

Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division | Nature Immunology

https://www.nature.com/articles/s41590-023-01578-y

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