Post-exertional Malaise in Long COVID Patients
A fascinating study
We discussed this FASCINATING study yesterday in our weekly live zoom talks. I will be talking about it on YouTube as well. Will share once I have recorded it.
It has cleared up so many of my questions for reduced exercise capacity and post-exertional malaise in Long COID patients.
Summary of the study is the following:
1. Muscle biopsies were done on long COVID patients before and after strenuous exercises to trigger post-exertional malaise.
2. Biopsies showed muscle fiber atrophy, necrosis, and A SHIFT TOWARDS glycolytic fibers and away from the OXIDATIVE fibers. That is, the muscle fiber types changed.
3. Deposition of amyloids in the muscle.
4. Low quality of the mitochondrial function.
5. More glycolytic ATP generation than oxidative phosphorylation.
6. Infiltration of macrophages and T cells.
7. No B cells infiltration.
8. No capillary blockage, or endotheliitis.
10. No clots in the blood vessels.
11. No issues with the cardiovascular system.
12. Muscle recovered in about a week.
Links:
Jan 11, 2024 at 7:07 AM
Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications
https://www.nature.com/articles/s41467-023-44432-3
Jan 11, 2024 at 7:14 AM
A discovery in the muscles of long COVID patients may explain exercise troubles
Jan 11, 2024 at 8:18 AM
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications - PubMed
https://pubmed.ncbi.nlm.nih.gov/35195253/
Jan 11, 2024 at 8:19 AM
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
https://emedicine.medscape.com/article/335414-overview
Jan 11, 2024 at 7:04 AM
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause? | Physiology
https://journals.physiology.org/doi/full/10.1152/physiologyonline.2002.17.1.17#:~:text=Intracellular%20acidosis%20due%20mainly%20to,cause%20of%20skeletal%20muscle%20fatigue.
Jan 11, 2024 at 7:04 AM
Science Fact or Science Fiction? Lactic Acid Buildup Causes Muscle Fatigue and Soreness | Pfizer
Jan 11, 2024 at 7:05 AM
Glycolysis - Wikipedia
https://en.wikipedia.org/wiki/Glycolysis
Jan 11, 2024 at 7:05 AM
Human Skeletal Muscle Fiber Type Classifications
https://academic.oup.com/ptj/article/81/11/1810/2857618
Jan 11, 2024 at 7:06 AM
Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473039/
Jan 11, 2024 at 7:06 AM
Muscle Hypertrophy - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/muscle-hypertrophy
Jan 11, 2024 at 7:07 AM
Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications
https://www.nature.com/articles/s41467-023-44432-3
Jan 11, 2024 at 7:14 AM
A discovery in the muscles of long COVID patients may explain exercise troubles
Fascinating and validating for those struggling with this syndrome. Thank you.