Inflammation - Lecture 1
Omega-6 and Arachidonic Acid - COX Pathway
Dear Kool Beens,
Yesterday we discussed how the omega-6 and Arachidonic Acid pathway works. We discussed cyclooxygenase enzymes. Lipoxygenase and CYP450 will be discussed in the coming talks.
We also discussed the following drugs:
1. Aspirin, why is cardioprotective in low dose and why does it not hurt the stomach lining as much as ibuprofen. Similarly, why aspirin has a lower risk of cardiovascular events.
2. Ibuprofen, Naproxen: their difference from aspirin. Why they tend to hurt stomach lining a little more than aspirin and why there is the cardiovascular and renal issues that can occur at high doses.
3. We also discussed why aspirin reduces the clotting tendency.
Next lecture on Tuesday and Wednesday of the next week. Become a substack member, or patreon, or drbeen.com member to get access to these live talks and their recordings on drbeen.com (Tuesday talks are recorded.)
Reference links:
URL list from Wednesday, Jun. 5 2024 8:47 AM
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed
https://pubmed.ncbi.nlm.nih.gov/16531187/
Arachidonic acid mobilization by stimuli of the innate immune response | Inmunología
Chronic Inflammation - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK493173/
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00443-w
Prostacyclin - Wikipedia
https://en.wikipedia.org/wiki/Prostacyclin
Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039135/
Membrane Phospholipid - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/nursing-and-health-professions/membrane-phospholipid
Arachidonic acid mobilization by stimuli of the innate immune response | Inmunología
hey dr. been. i am a paid subscriber, and happy to support you here on substack where you aren't censored. sometimes i miss these zoom lectures.. is there any way to view them afterwards? i suspect no, and no problem if not just thought i'd ask. thank you for all your awesome work :)