Dear Kool Beens,
Wanted to share two important talks. One on weathering winter better, and the other one is to have a healthy life with slower aging (MNM is important.)
In my talk that I presented yesterday I discussed a new study that showed the benefits of keeping nose warm during the winter time - it can be a life savor for some/vulnerable.
1. There is new research from Harvard showing that the nasal immunity against pathogens drops by 50% due to the cold temperature knocking out extracellular vesicles. Fascinating find. I talked about it yesterday:
My talk on this study:
2. MNM and other age-reversing possibilities are around right now. Hear this talk from Sinclair who is leading the research on SIRTuins. Essentially there are three methods to reverse the age:
1. mTor switching.
2. AMPK switching.
3. SIRTuin modulation.
Note: antioxidants have not shown much promise.
Check in the video the mice that have been artificially aged or reverse aged.
Love
Mobeen
References
Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity - Journal of Allergy and Clinical Immunology
https://www.jacionline.org/article/S0091-6749(22)01423-3/fulltext#%20
Cold exposure impairs extracellular vesicle swarm-mediated nasal antiviral immunity
https://www.jacionline.org/action/showPdf?pii=S0091-6749%2822%2901423-3
MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19 - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910799/#:~:text=In%20fact%2C%20miRNAs%20have%20been,or%20by%20enhancing%20the%20expression
Why colds and flu viruses are more common in winter | CNN
https://www.cnn.com/2022/12/06/health/why-winter-colds-flu-wellness/index.html
Well, the cold nose study results makes a lot of sense and certainly explains the uptick in respiratory issues in the cold weather!! Brilliant!
Sinclair's 'research' is not reproducible - and used inbred mice ... and the results were confounded by fluorescein dye . he also promotes Metformin - which has been debunked - metformin also blocks the benefits of exercise
https://youtu.be/vpxQoGk_ryg